If you mean, “Can I turn my custom insert 180 degrees?” the answer is yes. You can plan inserts with this in mind. Here are some examples of inserts that were planned in one orientation, but the owner is using them turned around. What was at 12:00 is now at 6:00.
Here is our Eric template…

And here is an insert designed using the Eric template, turned 180 degrees in its drawer.
The following is our Jill template…

And here is an insert designed with the Jill template turned 180 degrees in the drawer.
Here is our Andrea template…

And here is an insert designed with the Andrea template and turned 180 degrees in the drawer.
So, yes, turning an insert around in your drawer works just fine.
What’s not possible is flipping the insert over, pancake style. That’s a no-no for two reasons.
First, the underside of our inserts are unfinished. Second, and more importantly, the dividers would not function properly. The dividers cannot be removed from the bottom. This is an intentional design so that the entire insert can be lifted straight up, and, even if the insert is bottomless, the dividers will not fall through.
Bethany handles most of the customer service at Orderly Drawer. Being the wife of the creator/designer, she’s also privvy to the new design concepts that are cooking in Nathan’s mind. New designs have sometimes been developed based on what she hears from customers. So speak up! Your particular drawer organization needs might be the inspiration for our next product or template.